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This article contains information on a subject that is not considered canon in the Gravity Falls universe.
Pick-up Lines is a book used to help people find romantic companionship. It seems to be geared towards men picking up women, as the quote that the Hand Witch uses for the hiker starts with the word "girl."
In the "Little Gift Shop of Horrors" story, "Hands Off," Mabel gives this book to the Hand Witch to help her with her dating issues. After the Pines family leaves, the Hand Witch successfully says one of the pick-up lines to a hiker.
Pick-up Lines is a thick hardcover book. It is light purple with the words "PICK UP LINES" in all uppercase letters in a darker purple. There are dark pink hearts on both sides of the word "up."
"Girl, are those space pants? Because your butt looks out of this world!"
- 206. "Little Gift Shop of Horrors"